The body is good at getting accustomed to different substances and over time the potential of its effectiveness lowers. You can even say tolerance is built. Tolerance building is an easy process that people experience daily, for example – coffee or tea. People choose to drink it for boosting energy and concentrate to complete the project before deadlines. The one cup in the morning got replaced with several and the effects are significantly less intense than you initially started to drink coffee or tea.
CBD is frequently consumed, so you can assume that your body can get acclimatized to it just like coffee or tea. CBD or cannabidiol is used for treating medical conditions. So, daily use can build tolerance, which is a factor of concern. Before you visit Express Smoke Shop to buy premium quality CBD products like edibles, oil, bubbler, and even vaping equipment understand its connection with tolerance.
Understand the working of tolerance
Tolerance means the capacity to handle a substance consistently without adverse reaction or building resistance. Tolerance is categorized into three levels.
- Cellular – Over time the cells become desensitized or turn less responsive to a specific substance, so you will need to increase its dosage.
- Metabolic – Less amount of substance impacts the target spots.
- Behavioral – User becomes psychologically accustomed to substance effects.
The interesting fact is that tolerance will not fall within the three predefined categories. They can establish as a combination based on how your body responds.
The tolerance level to a specific substance differs from one person to another depending on their physiology and genetic structure. If one person develops tolerance in a week, it can take some time longer for another individual. Research has reported that CBD acts differently than THC [psychoactive compound] in terms of tolerance. Cellular tolerance with THC is highly common, which is not the case in the CBD compound. It is reported to cause a reverse tolerance mechanism.
How CBD works within your body?
Unlike THC, CBD interacts with ECS or endocannabinoid system differently. It does not bind directly with the CB1 & CB2 receptors but takes an indirect approach. So, theoretically speaking CBD is less prone to building tolerance like THC that binds directly to the receptors.
CBD enhances the binding affinity of certain receptors and influences endocannabinoid production that helps to maintain a state of homeostasis. Instead of the ECS being coerced to become overactive and eventually reject CBD, the non-psychoactive compound helps to regulate the imbalanced receptors. So, cellular tolerance is not exhibited as CBD does not bind directly.
CBD does not cause the high associated with THC. Users feel high or stoned when they consume THC but with CBD the effects are relaxed and relieved. Therefore it is not prone to behavioral tolerance.
According to the research report, CBD does not build tolerance but can decrease the CB1 receptor activation without any impact on ECS activities. Thus CBD has the potential to lessen the tolerance development and side effects of other cannabinoids.
Does CBD build tolerance?
The tolerance building capacity of CBD is still unclear. There is a need for deep and wide research. However, the early research reports appear favorable and on that basis, regular CBD use if led to tolerance doesn’t matter because the compound actively encouraged important functions associated with the ECS.